Shark Immunoglobulin Light Chains
نویسنده
چکیده
The humoral adaptive immune system of sharks is partly based on the same H2L2 heterodimeric antibody structure seen in all jawed vertebrates (reviewed in Flajnik 2002). The constituent vertebrate immunoglobulin (Ig) heavy (H) and light (L) chains provide obligate defense against pathogens and their toxins via neutralization, opsonization, and activation of the classical pathway of the complement cascade. The two IgL are generally identical to one another in any antibody, as are the two IgH, and this antibody is identical to all others made for plasma membrane expression or secretion by a particular B cell at a point in time. However, receptor editing and somatic ContentS
منابع مشابه
Isolation of a shark immunoglobulin light chain cDNA clone encoding a protein resembling mammalian kappa light chains: implications for the evolution of light chains.
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